Why you NEED a trip to the countryside: Exposure to rural microbes reduces risk of asthma, allergies and IBS in city-dwellers

April 30, 2014 2:14 pm Comments Off on Why you NEED a trip to the countryside: Exposure to rural microbes reduces risk of asthma, allergies and IBS in city-dwellers Views: 278
  • Exposure to ‘rural’ microbes not usually found in cities reduces the risk of asthma and allergies
  • It also reduces a person’s chance of developing irritable bowel syndrome
  • This could explain why city-dwellers who don’t leave the CBD often are more likely to have these conditions

Spending a weekend in the countryside could be good for your health, new research suggests

Most city-dwellers like to escape the hustle and bustle for a weekend in the countryside every once in a while.

And now, new research suggests it could be good for their health.

Scientists found exposure to microbes that thrive in rural environments can reduce the risk of developing asthma, allergies and other chronic inflammatory disorders.

They believe this could explain why there is a greater prevalence of these conditions among people of lower socioeconomic status who live in cities.

The researchers say these people have less access to green spaces meaning they are exposed to less of the microbes and that this, in turn, can cause chronic inflammation because of an immune system dysfunction.

They explained that when our immune systems are working properly, they trigger inflammation to fight off dangerous infections, but the inflammation disappears when the infection is gone. 

However, a breakdown in immune system function can cause a low level of inflammation to persist indefinitely. 

Such chronic inflammation can cause a host of health disorders.

‘Chronic inflammation can lead to all kinds of problems from irritable bowel syndrome to asthma to allergies and even depression,’ said Christopher Lowry, an associate professor in the University of Colorado Boulder’s Department of Integrative Physiology and a co-author of the paper. 

‘The rise of chronic inflammation and these associated disorders, especially among people living in the cities of developed countries, is troubling.’

Some scientists have hypothesised that the increase of chronic inflammation in wealthier Western countries is connected to lifestyles that have become too clean. 

The so-called ‘hygiene hypothesis’ is based on the notion that some microbes and infections interact with the immune system to suppress inflammation and that eliminating exposure to those things could compromise health.

But the idea that picking up more germs could boost our immune system does not at first seem to hold up when applied to low-income urbanites, who suffer disproportionately from both infections caused by germs and disorders linked to chronic inflammation. 

The authors of the new paper say this apparent lack of connection is due to a misunderstanding of the hygiene hypothesis.

Exposure to microbes that thrive in rural areas reduces the risk of developing asthma and allergies


Exposure to microbes that thrive in rural areas reduces the risk of developing asthma and allergies

The authors, who included scientists at University College London and at the University of Arizona, agree that microbes and some types of infections are important because they can keep the immune system from triggering inflammation when it’s not necessary, as happens with asthma attacks and allergic reactions.

But they say the infections that were historically important to immune system development have largely been eliminated in developed countries. 

The modern diseases we pick up from school, work and other crowded areas today do not actually lead to lower instances of inflammatory disorders. 

‘The idea that we’re too clean—that gives the wrong impression,’ said Dr Lowry. ‘You want people to wash their hands because hygiene is important to avoid infections that are harmful.’

The findings could explain why city-dwellers are more prone to developing chronic inflammatory disorders


The findings could explain why city-dwellers are more prone to developing chronic inflammatory disorder

During our evolutionary history, the human immune system was exposed to microbes and infections in three important ways: microbes were passed to infants from family members, people came into contact with nonpathogenic microbes in the environment, and people lived with chronic infections.

In order for those ‘old infections’ to be tolerated in the body for long periods of time, they evolved a mechanism to keep the human immune system from triggering inflammation. 

Similarly, environmental bacteria, which were abundant and harmless, were tolerated by the immune system.

In contrast, relatively modern ‘crowd infections,’ such as measles or chicken pox, cause an inflammatory response. 

The result is that either the sick person dies or the infection is wiped out by the inflammation and the person becomes immune from having the same infection again in the future.

Collectively, the authors refer to the microbes and old infections that had a beneficial impact on the function of our immune systems as ‘old friends.’ 

Exposure to ‘old friends’ plays an important role in guarding against inflammatory disorders, the authors said. 

Because the old infections are largely absent from the developed world, exposure to environmental microbes—such as those found in rural environments, like farms and green spaces—has likely become even more important.

The authors say this would explain why low-income urban residents—who cannot easily afford to leave the city for rural holidays —are more likely to suffer from inflammatory disorders. 

The problem is made worse because people who live in densely populated areas also are more likely to contract crowd infections, which cause more inflammation.

Like all people, better hygiene—like washing their hands more frequently, for example—could help them avoid crowd infections while more opportunities to visit green spaces could allow their immune systems to come into contact with more beneficial microbes.

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